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Behavioral Consequences of Calcium/Calmodulin Kinase II Inhibition in Rats: Author: Schwartz, Elizabeth Ann; Date: 2005-05-15; Program: Applied Psychology; Abstract: CaM kinase II (CaMKII) comprises 2% of hippocampal protein and plays an important role in learning and models of neural plasticity. Previous studies have employed a variety of techniques to inhibit CaMKII to investigate its role. This includes the use of chemical inhibition, genetic mutation and antisense; all have shown limitations. In the present study, RNA interference (RNAi) was used to inhibit CaMKII in the hippocampus of rats. The goal of this project was to determine if inhibition of hippocampal CaM kinase would result in behavioral deficits consistent with the role of this kinase. Thre...; Download File | View full details

The Dual Process Model of Stereotyping: Using Social Cognitive Research to Reduce Bias in the Workplace with an Emphasis in Gender Stereotyping: Author: Betzen, Nathan John; Date: 2005-12-15; Program: Applied Psychology; Abstract: As more women and minorities enter organizations, the issue of the glass ceiling fails to evaporate, due in part to the less favorable evaluations of women and minorities in the workplace. A likely cause for this is the lack of research and understanding in the business environment on stereotyping and its results. The following narrative review seeks to bridge the gap between social psychological and social cognitive research and business and Industrial/Organizational research on the topic through the introduction of a dual process model that identifies and attempts to correct for the harmful ...; Download File | View full details

Hippocampal damage and novelty preference in the ischemic gerbil: dissociating object and arrangement memory: Author: McNeill, Damon Lee; Date: 2007-05-15; Program: Applied Psychology; Abstract: The most insidious consequences of transient ischemia are its effect on the hippocampus and the memory systems it serves. The novelty preference test is a direct measure of memory function and has been used in the rat and primate animal models. The gerbil animal model has been used extensively to study the mechanism of ischemic brain damage; however, the novelty preference paradigm has not been used to study memory impairment in this species. In addition, the novelty preference paradigm has not been tested with models of ischemiA. In the present experiment, Mongolian gerbils were tested in two...; Download File | View full details

Behavioral Consequences following AAV mediated Hippocampal EAAC1 knockdown: Author: Coombs, Katie Marie; Date: 2007-05-15; Program: Applied Psychology; Abstract: The neuronal glutamate transporter EAAC1 (EAAT3) is present in hippocampal neurons to prevent excessive glutamate accumulation. Glutamate receptor-dependent synaptic plasticity is important for learning and memory. The present study investigates behavior associated with blocking the glutamate transporter EAAC1. To manipulate EAAC1 function, rats were intrahippocampally injected with a adeno-associated viral (AAV) vector encoding an EAAC1 antisense mRNA sequence or an AAV empty cassette. Twenty-eight days following surgery, rats were tested in a delayed matching-toplace (DMTP) watermaze task to...; Download File | View full details

Neuroprotective Potential of Methamphetamine: Behavioral and Histological Analysis: Author: Weeden, Christy Samantha Star; Date: 2007-05-15; Program: Applied Psychology; Abstract: Stroke is a leading cause of death and ischemic stroke is the most common form. The deficits that follow ischemic stroke include memory and learning impairment. There are presently no treatments that can combat the effects of ischemia after the attack has occurred. Immediately following insult, locomotor activity increases in rodent models. The goal of the current research is to determine if methamphetamine administration following ischemic attack will have neuroprotective effects and prevent changes in locomotor behavior that are observed following insult. Ischemic insult was induced in gerbi...; Download File | View full details

Novel pharmaceutical combination confers protection from delayed cell death following transient cerebral ischemia: Author: Chapman, Courtney Myfanwy; Date: 2009-05-15; Program: Applied Psychology; Abstract: Stroke is a leading cause of death and disability throughout the world; ischemia is the most common form of stroke. Medical procedures such as cardio-pulmonary bypass surgery can cause ischemic stroke can be caused. There are no treatments to limit neural impairment following stroke. The current research investigates neuroprotection offered by treatment with a novel drug combination consisting of Simvastatin™, Gemfibrozil™, Troglitazone™, and Spironolactone™. Animals were treated with the drug cocktail three weeks proceeding and one week subs...; Download File | View full details