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The Role of the Recruited Neutrophil in the Innate Response to Aspergillus fumigatus: Author: Bonnett, Colin Russell; Date: 2005-05-15; Program: Microbiology; Abstract: Strong clinical and experimental evidence links qualitative and quantitative neutrophil deficiencies to fatal infections caused by A. fumigatus. Yet the role of the neutrophil in mediating the protection observed in normal hosts remains largely unknown. Recent studies indicate neutrophils from CXCR2-/- mice are unable to migrate toward chemokine gradients of KC and MIP-2, rendering these animals susceptible to fatal aspergillosis. Mice with a mutation in the gene encoding for the gp91phox component of the NADPH oxidase lack the ability to generate the reactive oxygen metabolites used by phagoc...; Download File | View full details