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Structural Investigations of the Cancer-Associated Laminin Binding Protein and Nos L: A Novel Copper Binding Protein: Author: Taubner, Lara Marie; Date: 2005-12-15; Program: Biochemistry; Abstract: This thesis consists of two distinct projects, one on the metastasis-associated laminin binding protein and the other on the putative copper chaperone NosL, both related by the common aim of investigation of the relationship between protein structure and function using nuclear magnetic resonance techniques. In the first part of this dissertation, the role that the metastasis-associated laminin binding protein or LBP plays in the spread and development of cancer was investigated. Functional domains of LBP were delineated by limited proteolysis, overexpressed, and then assayed for their ability ...; Download File | View full details