Results :: Search Electronic Theses and Dissertations (ETDs)

Your search for Keyword proteomics and antioxidative stress study resulted in 420 match(es).

Back to search page

View next 25 results

New Statistical Methods for Analyzing proteomics Data from Affinity Isolation LC-MS/MS Experiments: Author: Sharp, Julia Lynn; Date: 2007-08-15; Program: Statistics; Abstract: The field of proteomics is exploding with statistical problems waiting to be explored. To obtain information on protein complexes, interactions between protein pairs is initially examined. This exploration is performed using `bait-prey' protein pull-down assays that use a protein affinity agent and an LC-MS/MS (liquid chromatography-tandem mass-spectrometry)-based protein identifcation method. An experiment generates a protein association matrix wherein each column represents a sample from one bait protein, each row represents one prey protein and each cell contains a presence/absence associat...; Download File | View full details

Investigating host response to viral infection through proteomics: a study of murine norovirus: Author: Furman, Linnzi M.; Date: 2008-05-15; Program: Biochemistry; Abstract: Norovirus causes roughly 23 million cases of foodborne illnesses in the United States each year. While this virus was characterized over 30 years ago, it remains non-cultivatable in human cells, resulting in an incomplete understanding of the host cell's response to infection. However, in 2004 murine norovirus (MNV) was found to be cultivatable in mice and has since been successfully cultured in RAW 264.7 cells. MNV has become an important model system for studying norovirus, as it is structurally and genetically similar to human norovirus. A global proteomics approach using fluorescently tagg...; Download File | View full details

The effects of supplemental feeding on stress hormone concentrations in elk: Author: Patrek, Victoria Elizabeth; Date: 2009-05-15; Program: Biological Sciences; Abstract: On twenty-two feedgrounds in western Wyoming, elk (Cervus elaphus) are provided with supplemental feed throughout the winter. Brucellosis seroprevalence of feedground elk is 26% whereas other elk in the Greater Yellowstone Ecosystem have historically had a brucellosis seroprevalence of 2-3%. The aggregation of elk during peak transmission allows brucellosis to persist in the feedground populations. In addition to creating the opportunity for disease transmission, the aggregation of elk on feedgrounds may have detrimental physiological effects. Studies have shown that chronically high stress ho...; Download File | View full details

Rural Grandparents Raising Grandchildren: Predictors of Parental stress: Author: Conway, Marcia Anne; Date: 2004-12-15; Program: Health and Human Development; Abstract: The number of grandparents raising grandchildren has increased dramatically in the West and throughout United States in recent years. Although research on grandparent caregivers is increasing, there remains little research that addresses the challenges and issues facing grandparents raising grandchildren in rural locales. To address this shortcoming, this study examines the parental stressors experienced by rural grandparent caregivers and explores individual, parental, and community level factors that may be related to stress including length of time in the primary caregiver role, grandparent...; Download File | View full details

Chemical approaches to probe environmental stress in Archaea: Author: Tarlykov, Pavel Victorovich; Date: 2009-05-15; Program: Biochemistry; Abstract: Little is known about strategies and mechanisms employed by thermophilic organisms to adapt to environmental stress. Sulfolobus solfataricus is a thermophile that belongs to Archaea, the third domain of life, and can be found in unusual habitats, such as the hot springs of Yellowstone National Park. This archaeon can tolerate high temperature, extreme acidity and high concentrations of heavy metals and other toxic substances. Thus, S. solfataricus has been chosen by many researchers as a model system for biochemical, structural, and genetic studies. In this work S. solfataricus has been expose...; Download File | View full details

A study of Demographics and Job-Related Categories that Influence the Quality of Teacher Work Life in Montana Schools with Indigenous Populations: Author: Terhune, Michael Neil; Date: 2006-05-15; Program: Education; Abstract: This study examined the demographics and job related factors that influenced the quality of teacher work life of 404 teachers in Montana schools that have a predominant enrollment of indigenous students. The Quality of Teacher Work Life Survey (QTWLS) was used to determine the teacher demographics, the factor structure of the QTWLS, and the perceived levels of Job-Related stress, and Satisfaction. Thirteen demographics contributed to the profile. Comparisons to the state wide profile were explored. Teacher perceptions of their job related satisfaction and stress factors were computed for Liker...; Download File | View full details

Sulfolobus as a Model Organism for the study of Diverse Biological Interests: Forays into Thermal Virology and Oxidative stress: Author: Wiedenheft, Blake Alan; Date: 2006-12-15; Program: Microbiology; Abstract: My research interests have focused on two distinct aspects of Sulfolobus biology: virology and oxidative stress. My major contribution to the emerging field of thermal virology has been the isolation, characterization and comparative genomic analysis of a spindle-shaped virus partical (SSV RH) infecting the thermoacidophilic archaeal host Sulfolobus solfataricus (18). Insights from this comparative genomic analysis have served as a platform for targeted structural studies, as well as providing molecular tools used to follow the viral life cycle in culture and for assessing the ecological signi...; Download File | View full details

Application of the Van Der Pauw Structure as a Piezoresistive Pressure Sensor - A Numerical study: Author: Law, Jesse Townsend; Date: 2007-08-15; Program: Mechanical Engineering; Abstract: This research characterizes a piezoresistive sensor under variations of both size and orientation with respect to the silicon crystal lattice for its application to MEMS pressure sensing. The sensor to be studied is a four-terminal piezoresistive sensor commonly referred to as a van der Pauw (VDP) structure. It is observed that the sensitivity of the VDP sensor is over three times higher than the conventional filament type Wheatstone bridge resistor. With MEMS devices being used in applications which continually necessitate smaller size, characterizing the effect of size and orientation of a V...; Download File | View full details

Static and Dynamic Behavior of stress Coated Membranes: Author: Nandurkar, Kuldeep Pandurang; Date: 2006-08-15; Program: Mechanical Engineering; Abstract: Large space mirrors need to be made of ultra-lightweight materials (membranes) that have very low densities and high flexibility (compliance) for packaging. A coating application necessary for optical reflectivity may also impart to these ultra-lightweight materials a desired shape and to help maintain that shape in the harsh environment of space. When a coating is applied on the membrane substrate, stresses develop in the coating due to atomistic processes. These stresses are fundamental to the final shape of the substrate. Coatings applied to the substrate in order to maintain a particular s...; Download File | View full details

Design and synthesis of fluorescent dyes for use in proteomic research: Author: Spicka, Kevin James; Date: 2008-08-15; Program: Chemistry; Abstract: proteomics is a rapidly developing field requiring powerful new technology in order to be able to detect proteins at increasingly lower concentrations. To aid in the detection of proteins at lower concentrations, DIGE dyes, a family of spectrally resolved fluorescent dyes, are currently available to proteomic researchers for 2D gel analysis. However, the demands of protein detection dictate that dyes that are even more sensitive and versatile be created. The syntheses of highly sensitive, water soluble BODIPY fluorophore dyes are described. These dyes are proposed to have the necessary sensiti...; Download File | View full details

Design and Evaluation of Compact Heat Exchangers for Hybrid Fuel Cell and Gas Turbine Systems: Author: Lindstrom, Joel David; Date: 2005-05-15; Program: Mechanical Engineering; Abstract: Hybridized Carbonate and Solid Oxide fuel cell power plants are currently under investigation to fulfill demands for high efficiency and low emissions. Selection and design of high performance heat exchangers are essential for such applications. In this work, various compact heat exchanger (CHEX) technologies pertinent to gas-gas recuperative duties are presented. The CHEX types considered include brazed plate-fin, fin-tube, microchannel, primary surface and spiral. Based on a comparative rating procedure, two CHEX designs namely, plate-fin and microchannel were chosen for further review. Plai...; Download File | View full details

Environmental and genetic factors leading to Mycobacterium Avium biofilm formation: Author: Geier, Henriette; Date: 2008-05-15; Program: Microbiology; Abstract: This dissertation investigated the role of environmental and genetic factors that lead to biofilm formation by the environmental and waterborne pathogen Mycobacterium avium. The bacterium causes respiratory and also cutaneous disease predominantly in immunocompromised patients, but infection also occurs in otherwise healthy individuals. M. avium has been frequently isolated from drinking water and it has been shown that the bacterium forms biofilms in drinking water systems. Biofilms show enhanced resistance to antibiotics and disinfectants and therefore are difficult to combat. Biofilm format...; Download File | View full details

Loneliness as experienced by women living with chronic illness in rural areas: Author: Marcille, Lisa Ann; Date: 2009-05-15; Program: Nursing; Abstract: Chronic illness is often accompanied by multiple life altering challenges for individuals especially those living in rural locations. Rural dwellers generally do not have readily accessible healthcare resources; as a result, there is a risk for poor heath related outcomes. Loneliness is one such outcome. The purpose of this study was to contribute to the existing body of knowledge related to loneliness as experienced by women living with chronic illnesses in rural areas. This was accomplished by identifying and exploring factors related to loneliness. The aims of this study were to: (a) to des...; Download File | View full details

Measurements of plant stress in response to CO2 using a three-CCD imager: Author: Rouse, Joshua Hatley; Date: 2008-12-15; Program: Electrical Engineering; Abstract: In response to the increasing atmospheric concentration of greenhouse gasses, such as CO2 produced by burning fossil fuels, which is very likely linked to climate change, the Zero Emissions Research Technology (ZERT) program has been researching the viability of underground sequestration of CO2. This group's research ranges from modeling underground sequestration wells to detection of leaks at test sites. One of these test sites is located just west of Montana State University in Bozeman, MT, at 45.66°N 111.08°W. At this site experiments were conducted to assess the viab...; Download File | View full details

Design, fabrication, and testing of the van der Pauw piezoresistive structure for pressure sensing: Author: Cassel, Robert Douglas; Date: 2008-05-15; Program: Mechanical Engineering; Abstract: The project characterizes a piezoresistive sensor under variations of both size and orientation with respect to the silicon crystal lattice for its application to MEMS pressure sensing. The sensor to be studied is a four-terminal piezoresistive sensor commonly referred to as a van der Pauw (VDP) structure. The VDP sensor is used primarily in sheet resistance measurements, but has also been determined to be useful in determining the stress components at a point on (100) and (111) silicon wafer surfaces. In a previous study, our team has determined the relation between the biaxial stress state a...; Download File | View full details

Rectangular pellicle beam splitter design: Author: Fraser, Jacob Lee; Date: 2008-05-15; Program: Mechanical Engineering; Abstract: This project investigates a pellicle beam splitter of rectangular form. A pellicle is a thin optical membrane and a beam splitter separates one optical path into two. The beam splitter under investigation is used at Arnold Engineering Development Center (AEDC) for optical component testing and mission simulation in cryogenic vacuum chambers. The conventional beam splitter had undesirable optical performance at cryogenic temperatures. The goal of this project was to use analysis to guide development of pellicle beam splitter prototypes to minimize thermal distortion. Engineers commonly use fini...; Download File | View full details

Intergranular Water and Permeability of the Lake Vostok Accretion Ice, Eastern Antarctica: Author: Jepsen, Steven Michael; Date: 2005-12-15; Program: Engineering; Abstract: The relative importance of nonhydrostatic stress and lattice-rejected impurities on the phase equilibrium of intergranular liquid water in the Vostok accretion ice, Eastern Antarctica, was examined in this study. In addition, experiments were conducted to examine the influence of intergranular water in ice on the permeability of a Light Non-Aqueous Phase Liquid (LNAPL) hydrocarbon. Sub-grain scale stresses in the Vostok accretion ice were simulated with anisotropic elastic and elastocreep finite element (FE) models and compared to X-ray dislocation topographs. The phase equilibrium conditions ...; Download File | View full details

Effects of Varying Habitats on Competition between Endangered San Joaquin Kit Foxes (Vulpes macrotis mutica) and Coyotes (Canis latrans): Author: Nelson, Julia Lynn; Date: 2005-12-15; Program: Biological Sciences; Abstract: Coyotes (Canis latrans) are the primary predator of endangered San Joaquin kit foxes (Vulpes macrotis mutica). Coyotes often associate with coverrich habitats while kit foxes use grasslands, alkali shrublands, and urban environments. Effects of varying habitats on coyote and kit fox competition are relatively unknown. I assessed exploitation and interference competition between coyotes and kit foxes in grassland and shrubland habitats to determine if kit foxes are niche displaced by coyotes. I evaluated habitat and spatial partitioning, diet, and prey abundance of kit foxes and coyotes, as wel...; Download File | View full details

Perceptions: Author: Muldoon, Dara Anne Hartman; Date: 2006-05-15; Program: Fine Arts; Abstract: My work is about the tension between the beauty of the female body and the underlying currents of dissatisfaction with that body, a stress stemming from a behavior that is enculturated in women from an early age and over many generations. The complex and diverse issues related to the way women feel about their bodies are revealed through a woman's obsessions; ranging from the annoyance of the imperfections on the skins surface to the internal desire to alter or even harm the body....; Download File | View full details

Identification of Novel Virulence Factors and Mechanisms of Pathogenesis from the Sexually Transmitted Protozoan Tritrichomonas foetus: Author: Higgins, Melanie Rae; Date: 2006-05-15; Program: Veterinary Molecular Biology; Abstract: Tritrichomonas foetus (T. foetus) is the cause of trichomoniasis in cattle. Little is known regarding the basis of virulence in this parasite. Early host-parasite interactions most likely affect the ability of the parasite to colonize the female reproductive tract. These early interactions shape the course of disease and ultimately control the outcome of pathogenesis. The aim of the studies herein is to provide insight into the factors that alter the progression of trichomoniasis. We examined how environmental stress and estradiol treatment affect pathogenesis of trichomoniasis. Acute T. foetu...; Download File | View full details

Patient perceptions of treatment options for chronic pain: Author: Benzschawel, Valerie C.; Date: 2008-05-15; Program: Nursing; Abstract: Chronic pain and pain management are frequently discussed and debated topics in American medicine today. The patients’ understanding of treatment options for management of chronic pain is a less frequently discussed topic. The purpose of this study is to explore patient perceptions of chronic pain treatment options. The framework for guiding this study was Neuman’s Systems Model (1995) based on the concepts of stress, client stability, and intervention. A review of the literature was completed that revealed very little information on the topic and therefore further research reg...; Download File | View full details

The Sinc-Galerkin Method for Problems in Oceanography: Author: Koonprasert, Sanoe; Date: 2003-12-15; Program: Mathematics; Abstract: The model for a wind-driven current with depth-dependent eddy viscosity is developed as a complex velocity formulation and a coupled system formulation. The numerical solutions, calculated by a Sinc-Galerkin method, are compared. A fully Sinc-Galerkin method in both space and time for a partial differential equation with time-dependent boundary conditions is developed. This entirely new technique is applied to the model for a wind-driven current with time-dependent viscosity. Several numerical examples are used to test the performance of the method. This fully Sinc-Galerkin method is then appl...; Download File | View full details

Applications of Quantum Field Theory in Curved Spacetimes: Author: Calderon, Hector Hugo; Date: 2007-12-15; Program: Physics; Abstract: While there is as yet no full theory of Quantum Gravity, some computations can still be performed in the regime where both gravitational and quantum effects are appreciable. These types of calculations, all of them perturbations, are performed in the hope they would provide guidance for the development of the full theory. This dissertation presents work related to three calculations using Quantum Field Theory in Curved Spacetimes. Primarily, the stress energy tensor of vacuum states is computed near Big Rip singularities, sudden singularities and in presence of a Schwarzschild-(anti) de Sitter...; Download File | View full details

The effect of earplugs on perceived sleep quality of acute care patients: Author: Martin, Kristy Ann; Date: 2008-05-15; Program: Nursing; Abstract: The purpose of this study was to evaluate the use of earplugs to improve perceived sleep quality in hospitalized patients. Sleep disruption is a common problem for hospitalized patients and has been shown to lead to physical and emotional complications. A variety of factors such as pain, illness, stress, worry, noise, lights and patient care activities contribute to disturbed sleep. Studies on sound in hospitals have shown that levels exceed recommendations by the Environmental Protection Agency. Limited research has shown that earplugs are a cost-effective, nonpharmacologic intervention with ...; Download File | View full details

Family Coping and Adaptation among Grandparents Rearing Grandchildren: Author: Porterfield, Fonda K; Date: 2007-08-15; Program: Health and Human Development; Abstract: Over the past decade, grandparent caregiving, in which grandparents take on the sole custody of their grandchildren without a parent present, has been one of the fastest growing family forms in the U.S. Most studies on grandparent caregiver functioning have focused on the challenges and deficits of grandfamilies. Little research has been conducted on the adaptive processes of grandparent caregivers and the coping mechanisms they employ to deal with parenting the second time around. The current study was based on qualitative data generated from 26 in-depth, face-to-face interviews with grandpar...; Download File | View full details

View next 25 results

Back to search page

print-friendly page | mobile-friendly page