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Analysis of the Small GTP Binding Protein Rac2: Author: Snodgrass, Meagan Alyssa; Date: 2005-08-15; Program: Microbiology; Abstract: Human neutrophils serve as the first line of immune defense against invading pathogens. In many cells, including neutrophils, Rac proteins are key regulators of many diverse cellular functions through their affects on cytoskeletal organization and in neutrophils, the NADPH oxidase complex, a critical mechanism for host defense. The primary purpose of this research is to examine the possibility that Rac2 interacts directly with the actin cytoskeleton. A different small GTP binding protein, Rap2 has been shown to interact with actin through direct binding. To test our hypothesis, GST-Rac2 and GS...; Download File | View full details