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Mechanism and Inhibition of the Phenylethylamine Oxidase from Arthrobacter globiformis: Author: Juda, Gregory Alexander; Date: 2005-05-15; Program: Biochemistry; Abstract: Copper amine oxidases (CuAOs) catalyze the oxidative deamination of primary amines to the corresponding aldehydes, utilizing O₂ as the oxidant with concomitant production of H₂O₂ and NH3. The discovery that the human vascular adhesion protein (HVAP-1) is a copper amine oxidase has sparked considerable interest in the mechanism and inhibition of these enzymes. With the potential for therapeutic applications, substantial efforts have been made to determine the molecular factors which govern inhibitor sensitivity and selectivity for copper amine oxidases. In order to contr...; Download File | View full details

Understanding the Molecular Factors Governing Inhibitor Potency and Oxygen Activation in Copper Amine Oxidases: Author: Shepard, Eric Michael; Date: 2006-05-15; Program: Biochemistry; Abstract: Copper amine oxidases (CuAOs) catalyze the oxidative deamination of primary amines to the corresponding aldehydes, with the concomitant reduction of O₂ to H₂O₂. CuAOs are known to have a multitude of physiological roles, and activity levels are upregulated in several pathological states. With the potential for therapeutic applications, substantial efforts were made to determine the molecular factors governing inhibitor selectivity. As such, several mechanism-based inhibitors were screened against CuAOs from bacterial, yeast, plant, and mammalian sources. The results pro...; Download File | View full details