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Molecular and Functional Characterization of Bovine C5a Receptor: Author: Nemali, Sailasree; Date: 2006-05-15; Program: Veterinary Molecular Biology; Abstract: Anaphylatoxin C5a is an important chemotactic factor for bovine neutrophils, and is the earliest inflammatory agent formed during bovine mastitis. Bovine neutrophils respond to C5a and its truncated form C5a des arg with similar affinities unlike human neutrophils. Therefore, to test the hypothesis that the bovine C5a receptor structure and signaling differ from that of the human C5a receptor, we cloned and analyzed the bovine C5a receptor. In the present investigation, the bovine C5a receptor encoding cDNA from bovine bone marrow was cloned and the recombinant C5a receptor protein was express...; Download File | View full details